Vioxx

Vioxx
rofecoxib ofecoxib (Chem. & Med.) A chemical substance ({C17H14O4S}, molecular weight 314.36) used in medicine as an analgesic to alleviate pain and inflammation; it is a synthetic compound, and is marketed by Merck & Co. under the trade name {Vioxx}, in tablets giving dosages of 12.5 or 25 milligrams. It is classed as a non-steroidal anti-inflammatory drug (NSAID). Chemically, it is 4-[4-(methylsulfony)phenyl]-3-phenyl-2(5H) furanone. Its chemical structure contains two phenyl rings and a furanone ring. It is believed to act by inhibition of prostaglandin biosynthesis, through inhibition of the enzyme cyclooxygenase-2 (COX-2); unlike {aspirin}, it does not inhibit cyclooxygenase-1. [PJC]

The Collaborative International Dictionary of English. 2000.

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  • VIOXX — VI OXX (v[imac] [o^]ks), prop. n. [Trade name, used by Merck & Co.] (Chem. & Med.) A trade name for {rofecoxib}. [Trade name] [PJC] …   The Collaborative International Dictionary of English

  • Vioxx — Strukturformel Allgemeines Freiname Rofecoxib Ander …   Deutsch Wikipedia

  • Vioxx — Rofécoxib Rofécoxib Général No CAS …   Wikipédia en Français

  • Vioxx — A drug that was being used for pain relief and was being studied for its ability to prevent cancer and to block the growth of new blood vessels to solid tumors. It belongs to the family of drugs called nonsteroidal anti inflammatory drugs. Vioxx… …   English dictionary of cancer terms

  • Vioxx — noun a Cox 2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004 • Syn: ↑rofecoxib • Usage Domain: ↑trade name • Hypernyms: ↑Cox 2 inhibitor …   Useful english dictionary

  • Vioxx — Vi·oxx vī .äks trademark used for a preparation of rofecoxib * * * Vi·oxx (viґoks) trademark for a preparation of rofecoxib …   Medical dictionary

  • Rofecoxib — Systematic (IUPAC) name 4 (4 methylsulfonylphenyl) 3 phenyl 5H furan 2 one Clinical data Pregnancy cat. C ( …   Wikipedia

  • COX-2 inhibitor — COX 2 selective inhibitor is a form of non steroidal anti inflammatory drug (NSAID) that directly targets COX 2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX 2 reduces the risk of peptic ulceration, and is the… …   Wikipedia

  • Rofecoxib — Nombre (IUPAC) sistemático 4 (4 metilsulfonilfenil) 3 fenil 5H furan 2 ona Identificadores …   Wikipedia Español

  • Merck & Co. — Merck Co., Inc. (Merck Sharp Dohme (MSD) outside the United States and Canada) Type Public Traded as NYSE:  …   Wikipedia

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